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欧盟评估一种内切-1,4-β-木聚糖酶的安全性

放大字体  缩小字体 时间:2021-05-07 15:16 来源:食品伙伴网 作者: 泽夕   
核心提示:2021年4月29日,欧盟食品安全局就一种内切-1,4-β-木聚糖酶(endo‐1,4‐β‐xylanase)的安全性评价发布意见。
   食品伙伴网讯  2021年4月29日,欧盟食品安全局就一种内切-1,4-β-木聚糖酶(endo‐1,4‐β‐xylanase)的安全性评价发布意见。
 
  据了解,这种食品酶是由转基因枯草芽孢杆菌菌株DP‐Ezd31生产的。经过评估,专家小组认为,在预期的使用条件下,不能排除饮食暴露引起过敏和诱发反应的风险,但这种情况发生的可能性很低。在缺乏适当的毒理学研究的情况下,专家小组无法就食用酶的安全性得出结论。部分原文报道如下:
 
  The food enzyme endo‐1,4‐β‐xylanase (4‐β‐d‐xylan xylanohydrolase; EC 3.2.1.8) is produced with a genetically modified Bacillus subtilis strain DP‐Ezd31 by Danisco US Inc. The production strain of the food enzyme contains multiple copies of a known antimicrobial resistance gene. However, based on the absence of viable cells and DNA from the production organism in the food enzyme, this is not considered to be a safety concern. The production strain was not shown to meet the criteria for Qualified Presumption of Safety (QPS) approach to safety assessment. The substitute studies provided were not considered suitable for the toxicological assessment of this food enzyme. A search for similarity of the amino acid sequence to known allergens was made and no match was found. The Panel considered that, under the intended conditions of use, the risk of allergic sensitisation and elicitation reactions by dietary exposure cannot be excluded, but the likelihood for this to occur is considered to be low. In the absence of suitable toxicological studies, the Panel cannot conclude on the safety of the food enzyme.
 
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日期:2021-05-07
 
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